A research team has used new in vitro and cell culture models to demonstrate that a lipid anchor on the outer membrane of nerve cells effectively inhibits the aggregation of the prion protein, which is a hallmark of neurodegenerative diseases like Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease. The findings suggest that membrane anchoring stabilizes the folding of the prion protein and could offer insights into the development of therapeutic strategies for prion diseases.
Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and cell culture models to show that a lipid anchor on the outer membrane of nerve cells inhibits the aggregation of the prion protein.
In order to gain new insights into the underlying processes, the researchers have developed new models to explore the role of a membrane anchor on the folding and aggregation of PrP in vitro and in neuronal cells. The experiments showed that anchoring to membranes stabilizes the folding of PrP and effectively inhibits aggregation."What's interesting is that the clumping of membrane-anchored PrP could be induced by pre-formed protein aggregates," says Jörg Tatzelt.
Many neurodegenerative diseases, such as dementia, are characterized by the abnormal aggregation of proteins inside cells, and treatments are being developed to break them up. But new research ... Prion diseases, such as Creutzfeldt-Jakob Disease , are fast-moving, fatal dementia syndromes associated with the formation of aggregates of the prion protein, PrP. How these aggregates form ...
Human prion diseases include Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease . A new study reports a significant advance in the development of mouse models of human ...Brain Cells Remain Healthy After a Month on the International Space Station, but Mature Faster Than Brain Cells on Earth
Prion Diseases Protein Aggregation Neurodegenerative Diseases Lipid Anchor Cell Membrane
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