The investigative phosphodiesterase 4B inhibitor appears better than placebo at protecting against decline in lung function over 1 year.
SAN FRANCISCO — The investigational oral agent nerandomilast was superior to placebo at slowing the decline in forced vital capacity among patients with progressive pulmonary fibrosis , results of the phase 3 randomized
Nerandomilast is an oral preferential inhibitor of PDE-4B that has shown both antifibrotic and immunomodulatory effects in preclinical models. The adjusted mean change in FVC at week 52, the primary endpoint, was −98.6 mL for patients assigned to nerandomilast 18 mg, −84.6 mL for those assigned to nerandomilast 9 mg, and −165.8 mL for those assigned to placebo.At the time of data cutoff, a first acute exacerbation of ILD, hospitalization for a respiratory cause, or death — a key composite secondary endpoint — occurred in 95 patients on the 18-mg dose, 110 on the 9-mg dose, and 122 patients on placebo.
“I think there is a lot of debate what is the best endpoint. I think it’s the best endpoint we currently have,” she replied.
IPF Idiopathic Pulmonary Fibrosis (IPF) Cystic Fibrosis Lung Fibrosis Pulmonary Fibrosis Lung Interstitial Lung Disease Colorado Diarrhea Diarrhoea Board Certification Boards Board Recertification Computed Tomography CT Ct Scan Grant Immunocompromise Immunocompromised Immunosuppression Washington Pneumonia
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