A higher dose of cisplatin given once every 3 weeks provided better locoregional control than a lower weekly dose in patients with locally advanced head and neck cancer.
once every 3 weeks provides superior locoregional control and may offer longer overall survival than 30 mg/mcisplatin once a week in patients with locally advanced head and neck cancer . Aside from hearing dysfunction, adverse events were similar between the two groups.Cisplatin is traditionally administered once every 3 weeks in patients with locally advanced head and neck cancer , but a lower dose option, given once a week, was introduced to reduce the likelihood of adverse events.
In early findings from a phase 3 trial, researchers reported worse locoregional control but no difference in disease-free or overall survival with the once-a-week schedule. The long-term analysis provides updated findings, with outcomes at a 7-year follow-up. The trial enrolled 300 patients with locally advanced head and neck cancer randomly assigned to receive cisplatin either once every 3 weeks concurrently with radiotherapy. Most patients had oral cavity cancer and about 90% were men.
The primary outcome was local or regional progression and secondary outcomes included overall survival, progression-free survival, and late adverse events.At 5 years, researchers reported worse locoregional control rates among patients receiving cisplatin once weekly vs once every 3 weeks , with a 44% higher risk for failure with the weekly dose and median overall survival was longer for those receiving weekly cisplatin , but the difference was not statistically significant (HR, 1.21; 95% CI, 0.
Head And Neck Cancer Head And Neck Cancer (HNC) Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Neck Cervical Region Of Neck Dentistry Oral Health Oral Medicine Dental Health Dental Oral Healthcare Oral Health Care Radiation Therapy Radiotherapy Radiation Oncology Dry Mouth Xerostomia Artificial Intelligence Deep Learning AI NPL
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