Nearly one-third of people with depression don't respond to widely available treatments, highlighting the need for medications that work in different ways.
“The ketamine discovery is considered one of the biggest breakthroughs in depression research in 50 years,” said a co-lead author of the new study, Peter Nagele, professor of psychiatry and behavioral neuroscience and chair of anesthesia and critical care at the University of Chicago.
Every participant received all three treatments, as opposed to a randomized controlled clinical trial, where one group receives the treatment and the other is given a placebo. While this design allowed the researchers to compare people to themselves, rather than to other people, it also may have muddied the results since a lasting effect of one treatment may have boosted the outcome of another, Das said.
“What I would like to see is the comparison of this with ketamine. If they sourced similar effects, I would use the nitrous oxide every time,” he said, noting that both drugs are cheap and easily administered, but nitrous oxide typically has milder side effects.
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