In a major potential step toward personalized therapy for atopic dermatitis, data suggest early, late, and no clinical response to dupilumab can be differentiated on a molecular basis.
, others respond more slowly, and the remainder do not respond at all demonstrated that molecular responses in these three groups are very different.
The criterion for differentiating the three response groups was an Investigator Global Assessment score of 0 or 1, signifying clear or almost clear skin . Early responders were those who met the criterion at both follow-ups, late responders were those who met this criterion only at the second follow-up, and nonresponders never met the criterion.
In the late responders, the proteome dysregulation was substantial relative to healthy controls at the first follow-up, but there was considerable improvement by the second follow-up. Although the change at the second follow-up was still not as robust as that seen in the early responders at either follow-up, Del Duca described the proteomic profile as a 45% improvement from the first follow-up.
When evaluating the proteome changes most implicated in immunoregulation, the investigators were able to show a correlation between worsening in the proteome and greater severity of AD as defined by IGA, Eczema Area and Severity Index, and body surface area involvement. The implications of the research are broad, and most importantly, it shows that therapeutic targets are likely to differ between patients with AD, according to Del Duca. Although proteomic studies have not yet been conducted with other treatments, these might provide further insight about how patients with AD differ in response across other drugs.
Atopic Dermatitis Atopic Eczema Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity Proteomics New York Biologic Therapy Biologics Blood Cytokines Eczema Europe European France French Hospitals Interleukins Natural Killer Cells NK Cells NK-Cells Patient History Medical History Severity Indices
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