Dr Jordan Axelrad discusses practical considerations for adding novel, targeted therapies in ulcerative colitis management.
Associate Professor, Department of Medicine, Division of Gastroenterology, NYU Grossman School of Medicine; Co-Director, Department of Medicine, Division of Gastroenterology, Inflammatory Bowel Disease Center at NYU Langone Health, New York, NY
I'm Jordan Axelrad, and I'm an associate professor of medicine at NYU Grossman School of Medicine and co-director of the Inflammatory Bowel Disease Center at NYU Langone Health. Today I'm going to be reviewing practical considerations for incorporating some of our novel non–anti-TNF-targeted advanced therapies in clinicalThe efficacy and safety of JAK inhibitors are dose dependent.
These drugs work relatively quickly. Although we have limited safety data, there was a very limited number of adverse events in the clinical trials, which largely mirrored those of ustekinumab. There is no-to-low risk for immunogenicity with IL-23 agents, again differing from our anti-TNF agents.
This class of drugs is unique in that there's a bit of work required prior to prescribing. Patients require a baseline, as this can cause symptomatic bradycardia. Patients are also required to have a fundoscopic exam — in particular, patients with a history of diabetes,, or macular edema. Patients are required to have annual skin cancer screening and should have that prior or shortly after treatment initiation.
Ulcerative Colitis Center Of Excellence Ulcerative Colitis Ulcerative Colitis (UC) UC - Ulcerative Colitis Colitis Inflammatory Bowel Disease IBD - Inflammatory Bowel Disease IBD Receptors Crohn's Disease Crohn Disease Regional Enteritis Crohn Crohn’S Fellowship Fellows Residency Residents Biologic Therapy Biologics Arrhythmia Bradycardia Remission
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