Researchers from University of New South Wales Sydney and St. Vincent's Hospital have identified a key pathway, involved in inflammation, which appears to be activated in people with long COVID who have symptoms of 'brain fog.'
Researchers from University of New South Wales Sydney and St. Vincent's Hospital have identified a key pathway, involved in inflammation, which appears to be activated in people with long COVID who have symptoms of"brain fog."
Patients who took part in this study had mild to moderate acute COVID-19 and were enrolled in the St Vincent's COVID-19 ADAPT study, a"Together, this study and a previous study in the ADAPT program show that long COVIDis associated with a dysregulation of the immune response," says Associate Professor Lucette Cysique, lead author of the study.
The discovery opens up possibilities for identifying and treating people who are experiencing the cognitive effects of long COVID and perhaps long COVID in general."These findings lay the foundation for the kynurenine pathway as a potential diagnostic and monitoring marker, as well as a possible therapeutic target," A/Prof. Cysique says.
The cognitive dysfunctions experienced by those with long COVID manifest most often as a lack of mental focus or clarity, or mental fatigue that is unusual compared to one's previous capacity, especially after a cognitively demanding task . This is associated with short-term memory problems, difficulty in multi-tasking or concentration over long periods of time.
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