Researchers have developed a new imagining system to monitor pluripotent stem cells during incubation. The new device -- INSPCTOR -- uses lens-free imaging technology integrated with thin-film transistors. The device is the same size as a standard culture plate, allowing multiple units to be monitored within a compact incubator.
By improving quality control during the growth process, this innovation could help accelerate advancements in customized regenerative medicine.
INSPCTOR leverages lens-free imaging technology integrated with thin-film transistors . TFT image sensors absorb scattered light passing through objects and shining onto a thin film, generating electrical charges. Each TFT sensor is the same size as a standard glass slide and can capture images of up to six culture chambers on a typical 8-well cell culture plate. As a result, six cultures can be observed independently, and multiple units can be managed simultaneously within a compact incubator.
To demonstrate the value of the INSPCTOR system, the researchers used it to monitor the transition of epithelial cells, which are stationary and tightly bound, into mesenchymal cells, which move more freely. This transformation plays a crucial role in many natural processes, such as embryonic development and wound healing. They demonstrated that the progression of cells could be precisely measured based on the light reaching the sensor beneath the culture plate.
Because the differentiation process is highly sensitive and prone to failure under incorrect conditions, verifying proper development is crucial. Moreover, the process is time-consuming, and quickly detecting any errors is essential. The ability to monitor cell growth becomes increasingly important as automation takes on a larger role in cell culturing.Traditional wearable thermal control devices use bulky and noisy components.
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