After the massive success of GLP-1 agonists to manage obesity, researchers are looking at new molecules that might hold similar potential.
XEN-D0501, a transient receptor potential vanilloid 1 antagonist, is gaining attention for its potential as an oral tablet to treat, and cardiovascular disease s. Dorte X. Gram, PhD, founder of Pila Pharma, a Swedish pharmaceutical company investigating XEN-D0501, first noticed the connection more than 20 years ago as a researcher at Novo Nordisk.
TRPV1 mediates the sensation of burning pain, often associated with inflammation and heat exposure. It also helps detect and regulate body temperature and influences the release of inflammatory mediators. In the central nervous system, it affects synaptic function and plasticity. Studies have shown that activating TRPV1 can help counter diet-induced obesity by increasing thermogenesis in brown adipose tissue and improving metabolic activity. TRPV1 agonists such as capsaicinshowed that participants with obesity taking capsinoid supplementation for 12 weeks experienced a reduction in body weight compared with those who took a placebo.
Obese Europe European Cardiovascular Disease Cardiovascular Disease (CVD) Metabolism Metabolic Pain Receptors CV Risk Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors Cardiovascular Risk Management Pain Management Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial Double-Blind Study Double-Blind Studies Single-Blind Study
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