A single dose of a dihydroergotamine mesylate nasal powder formulation appears to quickly and significantly reduce migraine pain, results of a new phase 3 study showed.
SAN DIEGO — A single dose of a dihydroergotamine mesylate nasal powder formulation appears to quickly and significantly reduce migraine pain, results of a new phase 3 study showed.
"We found STS101 to be safe, well-tolerated, and easy to use," study investigator Jessica Ailani, MD, director of MedStar Georgetown Headache Center and professor of clinical neurology, MedStar Georgetown University Hospital, Washington, DC, toldCurrently available DHE formulations are either not easy to obtain or not well-tolerated, said Ailani."Bringing more treatment options to people with migraine is part of our mission at the Georgetown Headache Center.
The double-blind study included 1424 mostly White, female patients with a mean age of 38 years and a history of two to eight moderate or severe migraine attacks a month, with or without aura. To be eligible, participants also had to have had migraines for at least a year with onset before age 50. Participants were randomly assigned to receive the DHE nasal powder or placebo. They self-administered a single 5.2-mg dose of the powder or placebo to treat one migraine attack of moderate to severe pain intensity.
Study participants had a favorable response to the treatment. Most considered it easy to use and reported they would likely use it if available. In addition, compared with their usual migraine medications, study participants indicated STS101 worked faster and more consistently, and it enabled them to return to normal more rapidly.
Migraine Headache Pain Pain Management Otolaryngology ENT Specialty Head And Neck Surgery ENT Speciality Headache Allodynia Nausea Aura Board Certification Boards Board Recertification Washington DC Washington - District Of Columbia
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