Positive findings on co-occurring psychiatric conditions build on an investigational drug's success in tamping down Tourette syndrome tics.
PHILADELPHIA — The investigational agent ecopipam reduces tic severity in children and adolescents with Tourette syndrome without exacerbating common psychiatric comorbidities, results of a new analysis suggest.-1 receptor antagonist reduced the primary endpoint of tic severity scores by 30% compared with placebo among 149 patients in the 12-week, phase 2b D1AMOND trial.
Patients were allowed to remain on medications without D2-receptor blocking activity for anxiety, OCD, and ADHD if the dosage was stable for 4 weeks before screening and not specifically prescribed for tics. The lack of weight gain with ecopipam is important, Gilbert stressed."Medicines that block D2 so often cause weight gain, and a lot of our patients, unfortunately, can be heavier already," he explained."We don't want to make that worse or put them at a long-term risk of
Attention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder (ADHD) Children Child Childhood Pediatrics Kids Tourette Syndrome Tourette's Syndrome Tourette's Disorder Tourette Disorder Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Anxiety Weight Gain Anxiety Disorder Weight Management
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