Investigating the interplay between white blood cell count and incidence of hyper-low-density lipoprotein cholesterolemia SciReports whitebloodcell WBC cellcount LDL hyperLDL cholesterol cholesteremia
By Dr. Chinta SidharthanMay 24 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Scientific Reports Journal, researchers from Japan conducted a longitudinal study investigating the association between white blood cell count and hypercholesteremia related to low-density lipoprotein .
High LDL levels are an established risk factor for cardiovascular disease, with genetic factors, gender, age, sedentary habits, and an increased intake of trans fats contributing to elevated LDL levels. Furthermore, although the nature of the association remains unclear, recent epidemiological research has indicated that white blood cell count is associated with hyper-LDL cholesterolemia.
High-performance liquid chromatography was used to estimate the hemoglobin A1C levels, and the fasting and non-fasting glucose concentrations were used to confirm diabetes. A standardized questionnaire gathered information on alcohol intake, smoking, daily activity levels, exercise, and regular medications.
The measured outcome was the elevation in LDL-cholesterol levels or the requirement for medications to lower LDL cholesterol levels during the follow-up period of 4.6 years on average. Although smoking is generally associated with high white blood cell count, the multivariable analysis indicated that the association between hyper-LDL cholesterolemia and white blood cell count was independent of all confounding factors, including smoking.
Hormone-sensitive lipase has been inhibited in adipose tissue due to hyperinsulinemia, with the level of free fatty acids increasing in hepatocytes. Elevated free fatty acids decrease apo B degradation in hepatocytes. Furthermore, through the degradation of LDL receptors, insulin resistance also increases the levels of circulating LDL.
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