Positive results of a phase 2 study support the potential to repurpose intranasal insulin and the SGLT2 inhibitor empagliflozin for Alzheimer’s disease.
The combination of intranasal insulin and the sodium-glucose cotransporter 2 inhibitor empagliflozin had positive effects on cognition and immune and inflammatory biomarkers in patients with mild cognitive impairment or early Alzheimer’s disease , in a phase 2 trial.
The phase 2 study included 47 patients with MCI or early AD, or amyloid positive controls with memory complaints. Patients were randomly allocated to one of four groups: Placebo, INI , empagliflozin , or INI plus empagliflozin . Compliance with treatment >90% in all groups. There were no differences between groups in treatment-related adverse events .
Alzheimer Disease Metabolism Metabolic CSF Cerebrospinal Fluid Mild Cognitive Impairment MCI - Mild Cognitive Impairment Minimal Cognitive Impairment MCI Mild Cognitive Impairment (MCI) Cognition SGLT2 Inhibitors Sodium-Glucose Transporter-2 Inhibitors Sodium-Glucose Co-Transporter-2 Inhibitors Sodium-Glucose Cotransporter-2 Inhibitors Diabetes Mellitus Type 2
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