Intermittent fasting vs. calorie restriction: which diet reduces the risk of type 2 diabetes more? NatureMedicine UniofAdelaide intermittentfasting caloriedefecit calorierestriction T2D type2diabetes research diet news
By Neha MathurApr 10 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Nature Medicine Journal, researchers performed a three-arm, open-label, randomized controlled trial between 26 September 2018 and 30 November 2021 among adults at a higher risk of developing type 2 diabetes .
Related StoriesIt also helped them quantify the parallel change in the two active study groups, i.e., iTRE and CR groups. However, only two clinical trials have documented greater improvements via IF compared to CR. Studies examining postprandial glycemia assessments followed by mixed meals are better indicators of T2D risk than fasting assessment studies. In addition, these test assessments have more physiological relevance than oral glucose tolerance tests.
These people showed not more than 5% weight fluctuations six months before study initiation. Also, they consumed no medications affecting glucose metabolism or weight management and did not have diabetes. The iTRE and CR groups received only one diet counseling during six months of dietary intervention, while the standard care group followed no meal plans and received no counseling.
As secondary outcomes, they compared iTRE vs. CR vs. standard care groups for changes in body weight, composition, fasting and postprandial glycemia markers, and cardiovascular and liver health. Similar to this large trial, three other pilot studies have compared the effects of IF vs. CR on the same parameters.
The prescription of iTRE vs. CR also elicited favorable lipid profile alterations. This parameter likely also reduced ectopic lipid and spiked peripheral glucose uptake.
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