Intermittent calorie restriction followed for 2 nonconsecutive days per week reduced the liver fat content in patients with MASLD more effectively than the standard diet.
Intermittent calorie restriction diet is more effective in reducing liver fat content than a standard-of-care diet in patients with metabolic dysfunction–associated steatotic liver disease , especially in those with obesity.Intermittent CR, which involves alternating periods of energy restriction and regular energy intake, has been proposed as a dietary intervention for MASLD.
Researchers conducted a 12-week randomized controlled trial to compare the effects of a 5:2 intermittent CR and standard-of-care diet in nondiabetic patients with MASLD with or without obesity at an outpatient clinic in Korea. Intermittent CR comprised a reduced calorie consumption on 2 nonconsecutive days a week and, on the remaining 5 days/wk, following the Korean Dietary Reference Intakes .The primary outcome was a relative reduction of ≥ 30% in the liver fat content measured by MRI-proton density fat fraction after 12 weeks.Researchers enrolled 72 participants , with 63 completing the trial; of these, 32 received an intermittent CR diet and 31 received a standard-of-care diet .
A higher proportion of patients in the intermittent CR group achieved a relative reduction of ≥ 30% in the liver fat content at 12 weeks than the standard-of-care group (72.2% vs 44.4%;These findings were even more prominent among those with obesity (61.1% in the intermittent CR group vs 27.7% in the standard-of-care group;Patients with obesity in the intermittent CR group also showed a greater relative reduction in body weight than those in the standard-of-care group (−5.5% vs −2.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.Fast Five Quiz: How Would You Manage MASLD and MASH?
NAFLD Non-Alcoholic Fatty Liver Disease Non-Alcoholic Fatty Liver Disease (NAFLD) MAFLD Metabolic Dysfunction-Associated Fatty Liver Dise Metabolic Associated Fatty Liver Disease Liver Diet Aminotransferase Ast Liver Enzymes Liver Studies Alt Transaminase Liver Fibrosis Liver Disease Hepatic Impairment Obesity Obese Metabolism Metabolic
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
GLP-1s May Protect Against Progression to Cirrhosis in MASLDTaking a GLP-1 receptor agonist was associated with a lower risk for cirrhosis and related complications in patients with metabolic dysfunction–associated steatotic liver disease and diabetes.
Read more »
Psoriatic Disease and MASLD: What Is the Connection?Dr Danielle Brandman explores the impact of metabolic dysfunction–associated steatotic liver disease (MASLD) in individuals with psoriatic disease.
Read more »
The Most Common Chronic Liver Disease in the WorldThe new term is MASLD, and the good news is that it’s largely reversible.
Read more »
Woman Loses 160 Pounds With Daily Walking, Intermittent FastingStephanie Thurrott is a writer who covers mental health, personal growth, wellness, family, food and personal finance, and dabbles in just about any other topic that grabs her attention. When she's not writing, look for her out walking her dog or riding her bike in Pennsylvania's Lehigh Valley.
Read more »
Subway unveils festive footlong cookie for the holidays — with a staggering calorie countSubway unveils it’s first holiday footlong cookie
Read more »
The 8 Best Low-Calorie Texas Roadhouse OrdersYour ultimate source for expert nutrition tips and health advice, covering wellness, healthy recipes, cooking hacks, food news, style trends and shopping.
Read more »