Researchers found that short-term intensive fasting enhances the immune function of red blood cells, including their ability to combat SARS-CoV-2, without affecting their oxygen-carrying capacity. The study reveals that this fasting regimen popular in Asia could offer a multifaceted benefit by amplifying the body's defenses without compromising essential functions.
By Vijay Kumar MalesuSep 4 2023 In a recent study published in the journal Immunity & Ageing, a group of researchers investigated the impact of short-term intensive fasting on the immune function of red blood cells and their capacity to combat infectious pathogens, including Severe Acute Respiratory Syndrome Coronavirus 2 .
Fasting, especially the STIF or 'beego' regimen popular in Asia, which combines water-only fasting with psychological exercises and concludes with refeeding, reshapes the immune landscape by redistributing cells. Further research is necessary to understand how short-term intensive fasting affects the immune response of red blood cells to infectious pathogens, especially SARS-CoV-2.
For the proteome sequencing in red blood cells, protein extraction involved a sequence of processes using various chemical reagents, centrifugation steps, and heating methods. Following protein extraction, proteins were quantified using Coomassie Brilliant Blue G-250. The extracted proteins underwent high pH RP separation, data-independent acquisition quantification, and MSstats differential analysis.
Related StoriesCartoon illustrating the argument of the immune function of red blood cells by STIF. STIF triggers the activation of the complement system via complement receptors on the membrane of red blood cells to enhance the immune response to various pathogens, particularly SARS-CoV-2.
An in-depth GSEA of the proteome profile in connection with the KEGG database disclosed that STIF significantly impacts how red blood cells respond to pathogens. This became especially intriguing when it was noted that STIF not only activated immune responses against various pathogens but also had a prolonged effect on coronavirus disease .
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