When you are feeling hungry, the brain takes the necessary steps toward consuming a meal. Many of these steps are not well known, but a new study reveals brain circuits and chemical messengers that contribute to the regulation of meal initiation and food intake.
The findings have implications for the development of improved therapies to manage obesity, a worldwide epidemic.
The Xu lab and colleagues have been studying the role of serotonin on feeding control for quite a long time. In this study, they focused on a little-known component of the serotonin regulation of food intake. They looked for brain circuits and neurotransmitters that regulate the activity of serotonin-producing neurons, activating or inhibiting them at the appropriate periods to reach balanced food consumption."We asked, how can we leverage this system to regulate feeding?" Xu said.
This work is important because it improves our understanding of how the brain manages body weight and feeding, specifically the roles of neurotransmitters in a specific phase of feeding behavior, meal initiation. This knowledge can inform the development of improved obesity drugs. This work was supported by USDA/CRIS S), National Institutes of Health and American Heart Association .Kristine M. Conde, HueyZhong Wong, Shuzheng Fang, Yongxiang Li, Meng Yu, Yue Deng, Qingzhuo Liu, Xing Fang, Mengjie Wang, Yuhan Shi, Olivia Z. Ginnard, Yuxue Yang, Longlong Tu, Hesong Liu, Hailan Liu, Na Yin, Jonathan C. Bean, Junying Han, Megan E. Burt, Sanika V. Jossy, Yongjie Yang, Qingchun Tong, Benjamin R. Arenkiel, Chunmei Wang, Yang He, Yong Xu.
Nervous System Diet And Weight Loss Obesity Brain Injury Nutrition Research Brain-Computer Interfaces Neuroscience
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