This article outlines the scientific methodologies and tools provided by Sino Biological for thedevelopment of CAR-T cell therapies.
Sponsored Content by Sino Biological Inc.Mar 14 2024Reviewed by Maria Osipova Since the FDA first approved CAR-T cell therapy in 2017, eight CAR-T drugs have emerged, six of which have been fully approved by the FDA. This groundbreaking cell therapy has brought about a series of innovations relating to the treatment of malignant hematological tumors, thus generating an increased interest across R&D circles in both academia and industry and the development of effective cancer treatments.
Sino Biological offers four antibody development platforms, such as phage display, hybridoma, FACS single B cell, and Beacon® single B cell, to help identify various solutions for scFv discovery. Sino Biological offers a diverse range of scFv development platforms suitable for the entire development process, from antigen design and preparation, animal immunization to acquisition of scFv molecules, supporting its pharmaceutical customers and helping them acquire their proprietary scFv sequences.
CAR-T preparation T cell activation There is an important step before CAR gen transduction and subsequent CAR-T cell expansion, and that is T cell activation. CD3/CD28 antibodies are the most commonly used for T cell activation in vitro. Sino Biological has developed GMP-grade CD3/CD28 monoclonal antibodies with high purity, high activity, and ultra-low endotoxin .
Lentivirus packaging system Lentiviral vectors raw materials which are crucial for achieving successful CAR-T therapy. Sino Biological offers transfection reagent, serum-free medium, and supplement for lentiviral production. Sino’s medium has allowed its pharmaceutical customers to complete IND filings with great success.Nucleic acid removal and detection Residual host cell DNA presents a safety risk where CAR-T drugs are concerned.
Sino Biological has developed high-grade cytokine ELISA kits, which can be utilized for the detection of representative cytokine levels to measure the killing activity and specificity of CAR-T cells on target cells.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Man killed in apparent car-to-car shooting on Mass. highway, police sayA man was killed and another person wounded in an apparent car-to-car shooting on Interstate 391 in Chicopee, Massachusetts, on Tuesday night, state police…
Read more »
The internet is integrated into virtually every aspect of lifeIt needs to be kept secure, and kept growing
Read more »
Co Down integrated primary school new-build gets green lightArds and North Down Borough Council gave go-ahead despite a number of objections
Read more »
Stage on Granite vs Integrated Granite Motion Systems — What to Choose for Precision Manufacturing?This article explores the difference between a stage on granite base and integrated granite motion systems
Read more »
Lab automation with integrated detection method unleashes new applicationsThe integration of a plate reader into Eppendorf’s epMotion liquid handling system facilitates researchers to use the system in a variety of new applications.
Read more »
Hands-On: 4iiii New Dual-Sided PRECISION 3+ PRO Powermeter, Integrated with Apple Find My4iiii's Dual-Sided PRECISION 3+ PRO unit has the same power-gathering features as the 4iiii PRECISION 3+, no with dual-sided power metrics.
Read more »