A study published in Respiratory Research suggests that inositol supplementation may be a viable and potential therapeutic avenue for idiopathic pulmonary fibrosis.
Fig. 5Effect of inositol exposure on the colony-forming ability of normal and IPF primary lung fibroblasts. Cells were seeded to grow and treated with indicated concentration of inositol for 14 days. Left: representative images of cell colonies. Right: quantification of colonies stained by crystal violet and counted under phase microscopy .Cell viability of IPF lung fibroblasts treated with inositol.
Left: representative images of stained invaded cells. Right: quantification of invaded cell number , nintedanib, or inositol intraperitoneally every two days. In total, there were four groups: saline; bleomycin plus vehicle; bleomycin plus nintedanib ; and bleomycin plus inositol . FigureA summarizes the experimental procedure and timelines for inositol supplementation in this study. After 14 days of drug treatment, lungs were collected and processed for histological and biochemical analysis.
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Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil - BMC Pregnancy and ChildbirthBackground Fetal loss is one of the most serious adverse outcomes of pregnancy. Since the onset of the COVID-19 pandemic, Brazil has recorded an unprecedented number of hospitalizations of pregnant women due to acute respiratory distress (ARD), thereby, we aimed to assess the risk of fetal deaths associated to ARD during pregnancy in Bahia state, Brazil, in the context of the COVID-19 pandemic. Methods This is an observational population-based retrospective cohort study, developed with women at or after 20 weeks of pregnancy, residents in Bahia, Brazil. Women who had acute respiratory distress (ARD) in pregnancy during the COVID-19 pandemic (Jan 2020 to Jun 2021) were considered 'exposed'. Women who did not have ARD in pregnancy, and whose pregnancy occurred before the onset of the COVID-19 pandemic (Jan 2019 to Dec 2019) were considered 'non-exposed'. The main outcome was fetal death. We linked administrative data (under mandatory registration) on live births, fetal deaths, and acute respiratory syndrome, using a probabilistic linkage method, and analyzed them with multivariable logistic regression models. Results 200,979 pregnant women participated in this study, 765 exposed and 200,214 unexposed. We found four times higher chance of fetal death in women with ARD during pregnancy, of all etiologies (adjusted odds ratio [aOR] 4.06 confidence interval [CI] 95% 2.66; 6.21), and due to SARS-CoV-2 (aOR 4.45 CI 95% 2.41; 8.20). The risk of fetal death increased more when ARD in pregnancy was accompanied by vaginal delivery (aOR 7.06 CI 95% 4.21; 11.83), or admission to Intensive Care Unit (aOR 8.79 CI 95% 4.96; 15.58), or use of invasive mechanical ventilation (aOR 21.22 CI 95% 9.93; 45.36). Conclusion Our findings can contribute to expanding the understanding of health professionals and managers about the harmful effects of SARS-CoV-2 on maternal–fetal health and alerts the need to prioritize pregnant women in preventive actions against SARS-CoV-2 and other respiratory
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