Infant exposure to monoclonal antibodies used to treat MS via breast milk does not negatively affect health or development out to 3 years, a new study shows.
"Most monoclonal antibody medications for multiple sclerosis are not currently approved for use while a mother is breastfeeding," even though the disease can develop during a person's reproductive years, study investigator Kerstin Hellwig, MD, with Ruhr University in Bochum, Germany, said in a news release.
The findings will be presented at the American Academy of Neurology 2024 Annual Meeting on April 14, 2024.Using the German MS and Pregnancy Registry, researchers identified 183 infants born to mothers taking mAbs while breastfeeding — 180 with a diagnosis of MS and three with a diagnosis of NMOSD. The infants were matched to 183 unexposed infants .started a median of 19 days postpartum and lasted for a median of 172 days.
In adjusted regression analyses, mAb exposure during breastfeeding was not significantly associated with annual hospitalization , developmental delay while breastfeeding, "and this study adds data for patients on natalizumab." "While infection rates of infants are reassuring, data on allergies in the exposed infants would be interesting to look at as well," she added. "While these infusions are not orally bioavailable, we do not know the full extent of impact on the neonatal gut microbiome."
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