A clinical trial will test the viability of lab-grown blood cells for transfusions.
The pair are healthy volunteers in the"Recovery and survival of stem cell originated red cells" trial, a one-of-a-kind clinical trial taking place at Addenbrooke's Hospital in Cambridge. The trial will ultimately include at least 10 participants, each of whom will receive a tiny transfusion of about one to two teaspoons-worth of lab-grown red blood cells, according to a statement .
Scientists expect the lab-grown cells to survive longer than standard cells, mostly because standard blood transfusions contain cells of varying ages while lab-grown cells can be made fresh."If our trial, the first such in the world, is successful, it will mean that patients who currently require regular long-term blood transfusions will need fewer transfusions in future, helping transform their care," chief investigator Dr.
These antigens distinguish the different blood groups, including the major groups — A, B, AB and O — and the lesser-known minor groups that are challenging to match between blood donors and recipients. When transfusion patients develop antibodies against specific blood groups, this puts them at risk of life-threatening immune reactions and therefore limits the types of blood they can receive in the future, according to a 2018 report in the journal Blood .
For the new trial, scientists extracted stem cells from blood donated by adult volunteers and allowed those cells to mature in lab dishes. The stem cells were"hematopoietic," meaning they could only mature into red blood cells, white blood cells and platelets.
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