Nicoletta Lanese is the health channel editor at Live Science and was previously a news editor and staff writer at the site. She holds a graduate certificate in science communication from UC Santa Cruz and degrees in neuroscience and dance from the University of Florida.
An HIV vaccine is one step closer to reality following a human trial that produced rare and elusive antibodies, a new study reports.
The challenge is that"these antibodies, naturally during infection, are very rare to find," said Thomas Hope, a professor of cell and developmental biology who studies HIV at Northwestern University Feinberg School of Medicine."It takes a couple years of real infection to make these antibodies," said Hope, who was not involved in the new study but has collaborated with some of its authors in the past.
By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over."We're gathering proof of concept that a vaccine could be made — can be made," Haynes told Live Science."We're having to coax the immune system, to guide the immune system in a way we've never had to do."
The idea behind the new vaccine is to make these mutations more probable by exposing the immune system to a series of reaction-triggering substances. These substances, or immunogens, contain short snippets of protein and bubbles of fat."What we're learning to do is design immunogens that can select for these rare mutations very efficiently," Haynes said.
The original goal of the trial was for everyone to get four doses, but it was paused after one participant given three doses had a serious allergic reaction to a vaccine ingredient called polyethylene glycol . PEG helps to stabilize certain types of vaccines in the body, but rarely, patients can have a reaction to it. The researchers have now reformulated the vaccine without PEG and will soon test the new version.
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