A new ScienceTM Viewpoint assesses the dual and sometimes conflicting roles of the ImmuneSystem in regulating pain, noting that T cells and macrophages can be either friends or foes depending on the specific context.
The immune system and the peripheral sensory nervous system communicate through hardwired and humoral routes using shared mediators and receptors.
On the basis of studies on pain sensitivity in rodents, the immune system can be viewed as both friend and foe. T cells and macrophages enhance pain via proinflammatory mediators and promote pain resolution via anti-inflammatory mediators and endogenous opioids.View all available purchase options and get full access to this article.
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