Researchers develop method to predict geneexpression across different tissues and celltypes VanderbiltU NatMachIntell
=0.536) surpassed the expected correlation in cortex . We report the Pearson correlation coefficient between the predicted values and the actual gene expression values. For any given target tissue, we used the same set of individuals to evaluate performance, namely individuals in the validation and test sets with collected gene expression measurements in all the corresponding tissues. Target tissues represented by less than 25 test individuals were discarded.
Extended Data Fig. 5 Performance comparison across gene expression imputation methods with per-gene metrics . Per-tissue comparison between HYFA and TEEBoT when using whole-blood and all accessible tissues as reference. We discarded target tissues represented by less than 25 test individuals. HYFA achieved superior Pearson correlation in 25 out of 48 target tissues when a single tissue was used as reference and all target tissues when multiple reference tissues were considered. For underrepresented target tissues , we considered all the validation and test individuals .
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