'These findings indicate that ovarian reserve in sickle cell disease was not reduced by hydroxyurea treatment, transfusion, or vaso-occlusive crisis.'
Hydroxyurea does not significantly reduce ovarian reserve in girls and women with sickle cell disease . Fertility preservation measures before hydroxyurea treatment may not be necessary.The study conducted in multiple French reference centers, analyzed ovarian tissue from 76 girls and young women with sickle cell disease who underwent ovarian tissue cryopreservation before hematological stem cell transplantation .
Participants had a median age of 10.2 years, with 65.8% being prepubertal. 46.1% had received hydroxyurea with a median daily dosage of 23.0 mg/kg and median exposure time of 44 months. Histological examination involved counting and categorizing follicles based on their growth stage and calculating follicle densities.
The primary outcome was to evaluate the effect of hydroxyurea on primordial follicle density, with secondary analyses on growing follicle density and the impact of vaso-occlusive crises.After adjusting for age, the density of growing follicles was marginally lower in the hydroxyurea group than in the hydroxyurea-naive group ("Overall, these findings indicate that ovarian reserve in sickle cell disease was not reduced by hydroxyurea treatment, transfusion, or vaso-occlusive crisis.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Sickle Cell Anemia Sickle Cell Anaemia Female Infertility I-Cell Disease Mucolipidosis Type Ii Inclusion-Cell Disease Mucolipidosis Ii Ml Ii Lysosomal Storage Disease Tissue Fertility Transfusion Transplantation Of Stem Cells Transplantation Of Hematopoietic Stem Cells Hematopoietic Stem Cell Transplant Stem Cell Transplantation Stem Cell Therapy
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