Imagine if lost, degenerated, or diseased parts of the brain could be regrown in the lab and transplanted for a new lease on life.
Human cortical organoids transplanted into mice not only connected with the host's vascular system, they reacted to pulses of light shone into the test subjects' eyes in similar ways to the surrounding brain tissue.
Over the course of several months, researchers used an innovative imaging system to measure electrical activity in the organoid that indicated an integrated response to visual stimuli. It's the first time scientists have been able to confirm functional connections in a transplanted human brain organoid in real time, largely thanks to improvements in implants capable of measuring subtle neurological signalling on a fine scale.
Less than a month after transplantation, researchers found their human organoids had formed functional synaptic connections with the rest of the mouse visual cortex.
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