Human cortical interneuron development unraveled

Two new Science studies aid our understanding of human cortical interneuron development and provide a framework for studying human disease. Learn more in a new SciencePerspective: Neuroscience

) reported conservation of the genetic networks that instruct interneuron identities between human and mouse, explaining how the same set of interneuron subtypes arises across species.

On page 402 of this issue, Paredes) find a distinctive cellular organization of the embryonic brain area where cortical interneurons are born and an extended period of neurogenesis in humans compared with rodents, explaining how interneuron numbers have increased. These studies aid our understanding of human cortical interneuron development and provide a framework for studying human disease.View all available purchase options and get full access to this article.

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