Gepotidacin works by blocking enzymes that bacteria need to unzip their DNA -- their operating instructions -- so they can multiply in the body.
It was developed in partnership with the US government, as one of 19 projects currently funded by the Biomedical Advanced Research and Development Authority, or BARDA, to combat antimicrobial resistance. Government investment was needed because new drugs are expensive to develop, and antibiotics tend not to turn large profits.
"The antibiotic pipeline is what we would call pretty leaky, because, you know, you end up with antibiotics dropping out," Liu said, meaning many of the drugs don't make it from the first to second phase of human trials. Another round will drop out between the second and third phase, typically because companies run out of funds to develop them.
Urinary tract infections can happen to both men and women of any age, but are more common in women and girls, who have shorter urethras that are closer to the rectum, making it easier for bacteria to infect the urinary tract.
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