How the cGAS–STING system links inflammation and cognitive decline

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How the cGAS–STING system links inflammation and cognitive decline
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Misplaced DNA triggers inflammation in the brain’s microglial cells.

First mentioned in the fifth century bc by the father of history, Herodotus, the water of the mythical fountain of youth is said to restore youthfulness and confer immortality.

Clearly, people have long been fascinated by the idea of delaying — or, even better, reversing — ageing. It is safe to say, however, that progress towards this goal has been slow. In the meantime, societies are ageing rapidly: by 2030, one in 6 people will be over 60, and between 2020 and 2050, the number of people over 80 is expected to triple (see

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