Our bone marrow the fatty, jelly-like substance inside our bones is an unseen powerhouse quietly producing 500 billion new blood cells every day.
That process is driven by hematopoietic stem cells that generate all of the various types of blood cells in our bodies and regenerating themselves to keep the entire assembly line of blood production operating smoothly.
"If you take a room full of 50-year-olds, some will be completely gray-haired, others will be salt-and-pepper, and a few will not have any gray hairs at all," said Jennifer Trowbridge, Dattels Family Endowed Chair and professor at the Jackson Laboratory."Logically, you'd expect to see the same kind of variation in the function of hematopoietic stem cells -- but until now, nobody has studied that directly.
The two growth factors -- Kitl and Igf1 -- are produced by mesenchymal stromal cells that surround the stem cells in the bone marrow microenvironment. By profiling the RNA transcriptome in these MSCs across individual mice, Trowbridge found that the decline of these growth factors correlated with age-associated molecular programs in hematopoietic stem cells.
Kira A. Young, Maria A. Telpoukhovskaia, Johanna Hofmann, Jayna J. Mistry, Konstantinos Kokkaliaris, Jennifer J. Trowbridge.Imagine being able to count the different types of blood cells being formed inside the tiny bones of a mouse and pinpointing the strings and clusters of cells within the bone marrow that are ...
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