A new study shows stimulating the vagus nerve in mice with colitis reduced stress-driven symptoms of inflammatory bowel disease by regulating SUMOylation, an immune response that triggers gut inflammation.
Researchers at Duke University School of Medicine have found that tapping into the nervous system could help reduce the gut inflammation that drives inflammatory bowel disease .
In 2022, Duke researchers, backed by the National Institutes of Health, began investigating whether stimulating the vagus nerve could affect SUMOylation and set off a natural anti-inflammatory response that calms immune responses and reduces inflammation. IBD cases are soaring -- up 50% in the last 15 years. Scientists are intensifying efforts to reduce inflammation-causing cells in the intestines and improve treatment options for the nearly 7 million people affected worldwide.
Researchers have long noted that stress plays a significant role in exacerbating IBD symptoms, and some have even described ulcerative colitis as psychosomatic. Ulloa warns that not all patients may respond similarly, and translating the findings from lab studies to clinical settings could lead to varying outcomes, or no benefit at all. The approach, called"bioelectronic medicine," is part of an emerging field where nerve stimulation is being explored to treat various inflammatory conditions from rheumatoid arthritis to Crohn's disease.
Ayman Youssef, Ata Ur Rehman, Mohamed Elebasy, Jatin Roper, Shehzad Z. Sheikh, Jorn Karhausen, Wei Yang, Luis Ulloa.Researchers report on the effects of a common herbal remedy on inflammatory bowel disease. A new study shows that DKT -- an herbal medicine containing ginger, pepper, ginseng, and maltose -- reduced ...
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