Experts explain why depression can be resistant to treatment, how we might be able to manage it, and how to support someone going through it.
started taking antidepressants about three years ago, but they haven’t worked well for me—at least, not yet. Trying different medications has felt like a roller coaster; at times I’ve felt empty and hollow, but there have been pockets of time where I’ve felt better than ever. Still, I haven’t found the exact right regimen yet. That's because I haveTreatment-resistant depression is pretty much what it sounds like.
TRD can also occur because of an incorrect diagnosis—and therefore, the wrong meds. “Depression can look like many things, but often what isn’t considered is a medical condition causing the depression," Douglas says."It may be bipolar or another related disorder that needs a mood stabilizer instead of an antidepressant."
Personal history and lifestyle factors, such as alcohol use and sleep hygiene, also can contribute to TRD. Just having depression can exacerbate problems with sleep, and so forth.
Here, again, patience is necessary. “Sometimes it takes a while to get adjusted to medications and or therapy before you see improvement,” says Douglas. She also says to share your full medical history and your lifestyle routines with your treatment team, so that they can recommend the best treatment for you. On your own, Douglas recommends maintaining a mood journal to track how you are feeling daily—for the benefit of your treatment team and your own self.
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