How do genomes evolve between species? Team explores the key role of 3D structure in malegermcells UAB_info NatureComms
during evolution. In particular, inherited chromosomal rearrangements are associated with physical and biochemical processes that are specific to the final stages of sperm production, after the meiotic cell divisions have completed.
"Our work shows the dynamics of chromatin remodeling during the formation of male gametes is fundamental for understanding which parts of the genome are located close to each other inside the nucleus, and are therefore more likely to be involved in chromosomal rearrangements, in different moments throughout male spermatogenesis," says Dr.
Furthermore, EBRs were not associated with meiotic recombination hotspots—indicating that these rearrangements most likely did not occur during meiosis in either males or females. Instead, EBRs were correlated with DNA damage locations in spermatids.
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