Researchers explore how lifestyle changes like diet and physical activity can influence microRNA expression in Alzheimer's patients, potentially offering new therapeutic avenues. The study fills a research gap in understanding how such lifestyle modifications could affect molecular mechanisms implicated in Alzheimer’s disease.
By Neha MathurAug 28 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Nutrients, researchers evaluate the modulatory effects of lifestyle changes, including diet and physical activity , on micro-ribonucleic acid expression in patients with Alzheimer’s disease .
AD, the most common type of dementia, is associated with the progressive and chronic loss of cognitive function. Some of the most notable risk factors for AD include older age, the presence of the apolipoprotein E4 gene, and family history. Several dietary components have been shown to reduce the accumulation of Aβ or support the clearance of these plaques, in addition to preserving brain health through other mechanisms. Polyphenolic compounds, for example, appear to reduce the aggregation of Aβ plaques, whereas omega-3 fatty acids may facilitate Aβ clearance, as well as reduce inflammation and neuronal loss.
In the context of AD, miRNAs have been implicated in several related pathways, including autophagy, synapsis, neuroinflammation, and cognitive function. In fact, one study has reported that both blood and brain samples obtained from AD patients exhibit significantly dysregulated expression of certain miRNAs involved in neuroinflammatory processes and Tau hyperphosphorylation.
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