Scientists from Scripps Research have made a breakthrough that could pave the way for new weight loss and metabolic health therapies. When exposed to cold temperatures, mammals instinctively burn more energy to keep their body temperature stable. This surge in energy usage prompts an increase in ap
Neuroscientists at Scripps Research have discovered a cluster of neurons in mice that activate food-seeking behaviors when exposed to cold temperatures, potentially paving the way for improved metabolic health treatments and weight loss strategies. The research suggests the ability to enhance fat burning without increasing appetite, by understanding the brain’s response to cold and its influence on feeding behaviors.
Neurons in the Xiphoid nucleus are activated by cold . A subset of this population promotes the animal to eat more in the cold. Credit: Scripps Research Eventually, the team zeroed in on a specific cluster of neurons called the xiphoid nucleus of the midline thalamus, showing that activity in these neurons spiked under cold conditions just before the mice stirred from their cold-induced torpor to look for food. When less food was available at the onset of the cold condition, the activity increase in the xiphoid nucleus was even greater—suggesting that these neurons respond to a cold-induced energy deficit rather than cold itself.
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