Aging clocks can measure the biological age of humans with high precision. Biological age can be influenced by environmental factors such as smoking or diet, thus deviating from the chronological age that is calculated using the date of birth. The precision of these aging clocks suggests that the aging process follows a program.
Scientists have now discovered that aging clocks actually measure the increase in stochastic changes in cells.
The loss of control over the cells and the increase in stochastic variation is not restricted to DNA methylation. Meyer and Schumacher demonstrate that the increase in stochastic variations also in the gene activity can be used as an aging clock."In principle it would be feasible to take this even further, allowing the stochastic variations in any process in the cell to predict age," Schumacher said.
Meyer and Schumacher hope that their findings on loss of regulation and the accumulating stochastic variations will lead to new interventions that can tackle the root cause of aging and may even lead to cellular rejuvenation. A target for such interventions could be repairing stochastic changes in DNA or improved control of gene expression.
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