A new study reveals how Vibrio cholerae bacteria activate the immune system, causing painful intestinal contractions. This research also sheds light on the gut's general defense mechanism against unwanted intruders, with potential implications for understanding chronic inflammatory bowel diseases.
A new study shows how one kind of bacteria, Vibrio cholerae, triggers painful intestinal contractions by activating the immune system. The research also finds a more general explanation for how the gut rids itself of unwanted intruders, which could also help scientists better understand chronic conditions like inflammatory bowel disease. After a meal of questionable seafood or a few sips of contaminated water, bad bacteria can send your digestive tract into overdrive.
Your intestines spasm and contract, efficiently expelling everything in the gut -- poop and bacteria alike. A new study from the University of Oregon shows how one kind of bacteria, Vibrio cholerae, triggers those painful contractions by activating the immune system. The research also finds a more general explanation for how the gut rids itself of unwanted intruders, which could also help scientists better understand chronic conditions like inflammatory bowel disease. 'This isn't a specific nefarious activity of the Vibrio bacteria,' said Karen Guillemin, a microbiologist at the UO who collaborated on the work with biophysicist Raghu Parthasarathy.'The gut is a system where the default is, when there's damage, you flush.' The research was led by Julia Ngo, a now-graduated doctoral student in Guillemin and Parthasarathy's labs, and published Nov. 22 in the journalVibrio cholerae is best known for causing cholera, a severe illness that infects millions of people per year, often via contaminated water. A related Vibrio species is frequently linked to food poisoning from shellfish. In past work, Parthasarathy's lab has shown that Vibrio cholerae bacteria amped up the strength of gut contractions in zebrafish. These fish, which are transparent as larvae, are a powerful tool for studying the dynamics of microbes in the gut because scientists can visualize what's happening in real tim
VIBRO CHOLERAE INTESTINAL CONTRACTIONS IMMUNE SYSTEM INFLAMMATORY BOWEL DISEASE GUT HEALTH
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