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Get a daily digest of the latest news in tech, science, and technology, delivered right to your mailbox. Subscribe now.that makes it difficult to cure. This process involves the spread of cancer cells from the breast to other parts of the body, like the lungs, bones, and brain, and is responsible for the high mortality rate associated with this disease.
According to Erdem Tabdanov, a lead co-corresponding author on the study and assistant professor of pharmacology at Penn State, the findings are groundbreaking in multiple aspects. He explains that dynein's involvement in cancer cell motility is a new discovery and that targeting dynein could be an effective way to prevent the spread of cancer cells.
The researchers used live microscopy to observe the movement of live breast cancer cells in two different systems. The first system was a two-dimensional network of collagen fibers, which represents the extracellular matrix that surrounds tumors. The second system was a three-dimensional network of microscopic hydrogel particles or microgels, which simulate soft tissue.
Amir Sheikhi, an assistant professor of chemical engineering and biomedical engineering at Penn State, discovered that dynein is crucial for the invasion of cancer cells using three-dimensional models that resemble a tumor. This breakthrough suggests a new strategy for managing cancer that involves stopping the cancer cells from moving instead of killing them with radiation or chemotherapy, which can also damage healthy cells.
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