A new method of cell engineering has allowed scientists to develop a fully human version of an organ resembling ovaries right in the lab—it could unleash a new way of treating infertility and diseases that target the ovaries.
. To make cells in the lab organize into an organoid, scientists give human skin and blood cells a protein concoction that reverts them to an embryonic-like state. From there, they can grow the cells into more specialized types that make up the organs they are designed to model.
Ovarian organoids made in this way typically rely on a mix of human and mouse cells—scientists only use the human cells to make germ cells, which go on to grow into eggs. Cells from mice recapitulate somatic cells in their organoid that would support germ cells in a real-life ovary. In the new study, the researchers added even more proteins to a subset of human cells so that they would mimic the development of a somatic cell. Not only was their model entirely derived from human cells, it also showed marked benefits compared to previous ovarian organoids. The new organoids produced DAZL, a protein associated with ovary maturation, in just four days—a process that took hybrid human-mouse ovarian organoids 32 days.
“The fact that this can be done within five days instead of the month required with human/mouse hybrid ovaroids will dramatically speed up the discovery of critical information about women’s health and reproduction,” Church said in the press release. The ability to
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