Rapamycin, a drug for transplant patients, has extended the lives of animals but is unproven in humans. That hasn’t stopped people from trying it.
To keep himself healthy into his eighth decade, David Sandler recently decided to go beyond his regular workouts and try something experimental: taking rapamycin, an unproven but increasingly popular drug to promote longevity.
Researchers have found that rapamycin can modify a kind of cellular communications system that gives cells certain directions - to grow when the body has plenty of food and to slow down when nutrients are scarce. The drug can dial down the signal to grow, causing cells to clear out accumulated junk and allowing them to run more efficiently.
“Mice may be a little different from humans when it comes to drug tolerance, diseases and reactions,” said Elena Volpi, a professor and longevity expert at the University of Texas Health Science Center at San Antonio. Rapamycin was collected by a scientific expedition in the 1960s from the soil of Easter Island, also known as Rapa Nui, one of the most remote inhabited places on earth. The FDA approved it in 1999 to help transplant patients tolerate their new organs. But scientists kept exploring how the drug worked and ultimately set the field of longevity medicine abuzz.“It was uncanny,” Attia writes in his best-selling book, “Outlive: The Science and Art of Longevity.
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