Researchers at St George's, University of London have discovered a technique that can kill skin cancer cells while minimizing damage to healthy cells. The findings are published in the journal Biology Open.
in the laboratory to see if it would stop them from dividing. The peptide was also tested on normal skin pigment cells and other skin cells called fibroblasts.
"We tried the p16 peptide on three lines made up of metastatic melanoma cells. All of those were nicely wiped out, yet it did little harm to the normal cells, which is very promising.
"One of the best strategies to address that gap is to find new treatments which attack cancer, while minimizing harm to. p16-related peptide could offer a promising new approach for those patients diagnosed with metastatic disease, where options for treatment are currently more limited." Adil Sheraz, consultant dermatologist and British Skin Foundation spokesperson added,"This research is an exciting development towards treating melanoma, the most lethal form of skin cancer. The protein p16-related peptide preferentially targets melanoma cells, preserving fibroblasts—which play a vital part in skin repair and regeneration—and causing minimal damage to other cells.
Further research is now needed to test the p16-related peptide on other types of healthy skin cells and to determine how the cancer-killing mechanism is triggered.Julia K. Soo et al, Preferential killing of melanoma cells by a p16-related peptide,
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