Data from four tirzepatide pivotal trials in people with type 2 diabetes showed ≥15% weight loss in 25% of those on tirzepatide, with seven factors significantly linked with greater weight loss.
Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit.who were adherent to their tirzepatide regimen in four pivotal trials of the agent, a quarter achieved at least a 15% cut from their baseline body weight after 40–42 weeks of treatment, and researchers found seven baseline variables that were significantly linked with a higher incidence of this level of weight loss.
The researchers aimed to identify predictors of a reduction in body weight of at least 15% with tirzepatide treatment at any of the three tested doses ― 5 mg, 10 mg, or 15 mg ― which were administered by subcutaneous injection once a week. Multivariate analysis of baseline covariates showed that these seven factors were significantly linked with ≥15% weight loss: higher tirzepatide dose, being female, being of White or Asian race, being of younger age, undergoing treatment with, having better glycemic control , and having lower non-high-density lipoprotein cholesterol level.
Mitchel L. Zoler is a reporter with Medscape and MDedge based in the Philadelphia region. @mitchelzoler
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