Linda Carroll is a regular health contributor to NBC News. She is coauthor of 'The Concussion Crisis: Anatomy of a Silent Epidemic' and 'Out of the Clouds: The Unlikely Horseman and the Unwanted Colt Who Conquered the Sport of Kings.'
High levels of niacin, an essential B vitamin, may raise the risk of heart disease by triggering inflammation and damaging blood vessels, according to new research. The report, published Monday in Nature Medicine, revealed a previously unknown risk from excessive amounts of the vitamin, which is found in many foods, including meat, fish, nuts, and fortified cereals and breads.
That finding led to two additional “validation” studies, which included data from a total of 3,163 adults who either had heart disease or were suspected of having it. The two investigations, one in the U.S. and one in Europe, showed that the niacin breakdown product, 4PY, predicted participants’ future risk of heart attack, stroke and death. The final part of the study involved experiments in mice. When the rodents were injected with 4PY, inflammation increased in their blood vessels.
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