High-level BPA exposure may affect male fertility IJMS_MDPI BPA expose menshealth fertility malefertility
By Dr. Sanchari Sinha Dutta, Ph.D.Aug 9 2023Reviewed by Benedette Cuffari, M.Sc. In a recent review published in International Journal of Molecular Sciences, scientists discuss the effect of bisphenol A on human male fertility.
BPA is an endocrine disruptor chemical capable of triggering the onset and development of various health adversities, including infertility. This chemical is vastly used for the production of phenol resins, polyacrylics, polyesters, epoxy resins, and polycarbonate plastics. Due to its structural similarity to 17 beta-estradiol, BPA can bind to alpha and beta estrogen receptors to trigger estrogenic effects. BPA can also bind to G-protein-coupled estrogen, gamma peroxisome proliferator-activated, and orphan nuclear estrogen gamma receptors, thereby leading to major cellular and endocrine disruptions.
Related StoriesBPA affects spermatogenesis by mimicking the activity of estradiol, thus leading to poor sperm quality and infertility. Moreover, BPA acts as an antagonist against the thyroid hormone receptor, which ultimately prevents the activity of thyroid hormones. In one study conducted on the general Danish population, BPA exposure was associated with increased levels of testosterone, estradiol, and luteinizing hormone . Another study conducted in low-industrialized area in China reported that low-level environmental exposure to BPA is associated with increased levels of LH and FSH in male smokers and decreased levels of total testosterone in overweight men.
Studies conducted on men with diagnosed infertility have found associations between increased urinary BPA levels and lower sperm count, sperm concentration, sperm vitality, sperm motility, and altered sperm morphology. In contrast, some studies comparing fertile men with infertile men have shown no association between BPA exposure and infertility.
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