A multicenter prospective study found no link between a high polygenic risk score for rheumatoid arthritis and increased toxicities from cancer radiotherapy.
A recent analysis found that patients with a high genetic risk for rheumatoid arthritis do not face an increased risk for acute or late radiation-induced toxicities, suggesting no need to alter treatment plans based on RA genetic risk. Having RA may increase patients’ risk for radiosensitivity, which could increase their risk for toxicities following radiotherapy. One explanation for this possible connection is that the genes linked to RA may overlap with those associated with radiosensitivity.
The researchers monitored normal tissue toxicity prospectively for 2 years after radiotherapy. Acute toxicity was defined as the maximum reported toxicity within 3 months of radiotherapy; late toxicity was defined as the maximum reported toxicity from 3 months to 2 years after radiotherapy. Looking at specific toxicities, individual acute or late toxicity endpoints were not significantly associated with polygenic risk scores in patients with breast cancer.
Toxicity Poisoning Toxins Radiation Therapy Radiotherapy Radiation Oncology Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Genomics Genomic Medicine Breast Cancer Malignant Breast Neoplasm Breast Carcinoma Genetics Lung Cancer Lung Carcinoma Cancer Of The Lung Prostate Carcinoma Malignant Prostate Neoplasm Prostate Cancer Cancer Of The Prostate
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