“There is in fact a greater than 3-fold risk with affected first-degrees family members,” Dr. Dawn Eichefield said.
— acne that manifests as an explosive worsening and ulceration of skin lesions and can be associated with systemic symptoms — heritability is a likely culprit.“There have been many studies showing us that it can run through families and there is in fact a greater than 3-fold risk with affected first-degrees family members,”, assistant professor of dermatology at Rady Children’s Hospital and the University of California, San Diego, said at the annual Maui Derm Hawaii conference.
“Severe acne formed a little later, around age 14,” said Eichenfield, who was not affiliated with the study. The researchers also found that 50%-60% of patients had family members with severe acne, mostly hemorrhagic lesions, “the kind that that we are always afraid of scarring,” she said. Acne fulminans is also associated with certain medications, including oral retinoids, androgens, and antibiotics. In addition, it presents as a dermatologic finding in some syndromes, including synovitis, pustulosis, hyperostosis, and osteitis ; autoinflammatory syndromes such as pyogenic arthritis,, researchers evaluated the demographic factors of acne fulminans in 212 patients identified in a literature review. Most were male, mean age was 16.6 years, 97.
Eichenfield advises clinicians to “be fearless” when working up acne fulminans. Recommended labs include a CBC, ESR, CRP, and LFTs. “I will get a CMP most of the time because I want to see how their kidneys are doing, but usually the kidneys are not affected,” she said. “If you’re going to use a systemic medication, you’re going to want to know whether or not the patient is pregnant and a radiograph to look for the body lesions.
Eichenfield disclosed being a speaker, consultant, and/or an investigator for several pharmaceutical companies. She has also received support from the Dermatology Foundation. All material on this website is protected by copyright, Copyright © 1994-2025 by WebMD LLC. This website also contains material copyrighted by 3rd parties.
Acne Vulgaris Acneiform Eruptions Acne Fulminans Acne Maligna Skin And Soft Tissue Infection Rosacea Acne Rosacea Bone Scan Bone Imaging Isotretinoin Inheritance Genetics - Inherited Condition Scar
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