Diabetes, prediabetes, and hyperglycemia were linked to accelerated brain aging, but physical activity and abstention from smoking and heavy drinking may mitigate much of this effect.
Diabetes and prediabetes are associated with accelerated brain aging with brain age gaps of 2.29 and 0.50 years, respectively. This association is more pronounced in men and those with poor cardiometabolic health but may be mitigated by a healthy lifestyle.
The brain age gap was calculated as a difference between chronologic age and brain age estimated from MRI data from six modalities vs several hundred brain MRI phenotypes that were modeled from a subset of healthy individuals. The brain ages of those with prediabetes and diabetes were 0.50 years and 2.29 years older on average than their respective chronologic ages.
Borderline Diabetes Brain Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Cardiometabolic Risk Cardiometabolic Risk Factors Exercise Physical Activity Hyperglycemia
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