We know the brain changes after traumatic injury, and now we have maps from mice showing what that change looks like.
Of particular interest were a group of neurons called somatostatin interneurons that control the input and output of local brain circuits and are among the most vulnerable to cell death following brain injury.
What the researchers saw was striking. Two months after an injury to the hippocampus, a brain region involved in learning and memory, neural circuits in the mice brains had reconfigured themselves.Surviving somatostatin interneurons in the hippocampus became 'hyperconnected hubs', rich with close-range connections but disconnected from long-range inputs; the same connectivity changes were also seen in distant areas of the brain, not directly injured.
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