Study identified that several specific bacterial species were significantly associated with colorectal cancer, challenging previous assumptions about established biomarkers once adjusted for important covariates.
By Dr. Chinta SidharthanMay 1 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Nature Medicine , a European team of researchers quantitatively characterized the microbiome profile to study the association between gut microbiota and malignant colonic transformations in colorectal cancer .
Recent research on the gut microbiome has revealed that shifts in the gut microbiota have been linked to various disease phenotypes. Studies have also reported an association between bacterial markers, such as an increase in Fusobacterium in the stool and lesions of patients with colorectal cancer. However, the ascertainment of risk factors of colorectal cancer and the role of confounding variables, which can improve population-wide screening, remains a challenge.
Furthermore, the approach of relative microbiome profiling, which expresses taxon abundance in percentages and is the predominantly used method in microbiome studies, presents various issues related to microbial compositions and relative profile interpretations. Therefore, a quantitative microbiome profiling approach, which uses normalized comparisons of profiles across differing conditions or samples, helps lower the rates of false negatives and false positives.
Results The results showed that established biomarkers of colorectal cancer, such as Fusobacterium, were not significantly associated with colorectal cancer diagnosis after controlling for covariates such as body mass index , fecal calprotectin , and transit time .
Colorectal Colorectal Cancer Microbiome Bacteria Colon Colonoscopy Dysbiosis Malignant Medicine Mortality Research
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