Bacterial and nonbacterial components of the gut microbiome and their function can accurately differentiate children with autism spectrum disorder from neurotypical children.
The findings could form the basis for development of a noninvasive diagnostic test for ASD and also provide novel therapeutic targets, wrote investigators, led by Siew Ng, MBBS, PhD, with the Microbiota I-Center , the Chinese University of Hong Kong.The gut microbiome has been shown to play a central role in modulating the gut-brain axis, potentially influencing the development of ASD.
After controlling for diet, medication, and comorbidity, they identified 14 archaea, 51 bacteria, 7 fungi, 18 viruses, 27 microbial genes, and 12 metabolic pathways that were altered in children with ASD. "The reproducible performance of the models across ages, sexes and cohorts highlights their potential as promising diagnostic tools for ASD," the investigators wrote.
Autism Autism Spectrum Condition Autism Spectrum Disorder (ASD) Children Child Childhood Pediatrics Kids Microbiome Microbiota Bacteria Bacterial Infection Genetics Genomics Genomic Medicine Artificial Intelligence Deep Learning AI NPL Machine Learning ML Natural Language Processing Artificial Neural Networks Board Certification Boards
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